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KMID : 0616120190500030205
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 3 p.205 ~ p.218
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Single Oral Dose Toxicity Test and Four Weeks Repeated Oral Dose Determination Test of Oplopanax elatus (Nakai) Nakai Hydrothermal Extract Powder in Sprague-Dawley Rats
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Yoo Nam-Ho
Kwon Yong-Soo
Chun Hyeon-Soo
Ahn Kyu-Sup
Kim Hye-Jin
Ryu Hyeon-Yeol
Lee So-Min
Song Kyung-Seuk
Park Byung-Jun
Kim Myong-Jo
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Abstract
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This study was conducted to investigate the toxicity symptoms and approximate lethal dose (ALD) of Oplopanax elatus (Nakai) Nakai hydrothermal extract powder by single oral dose toxicity and 4 weeks of repeated oral dose determination. The Sprague-Dawley (SD) male and female rats were treated with 1,250 (low- dosage group), 2,500 (medium- dosage group) and 5,000 (high- dosage group) mg/kg. In the single oral dose toxicity test, no dead animals and toxic symptoms were observed during the experiment. And there were no related with anomalies in normal weight changes and autopsy results. In the four-week repeated oral dose determination test, no death animals and toxicity symptoms were observed during the experiment, and there were no abnormal results in weight changes, feed and negative intake measurements. Results of eye examination, urinalysis, hematological values and serum biochemical values, gross findings and absolute organ were not of singularity. These result demonstrated that no toxic symptoms were observed by the test substance Oplopanax elatus (Nakai) Nakai hydrothermal extract powder under this test condition, and the non-toxic content is determined to be 5,000 mg/kg/day.
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KEYWORD
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Four weeks repeated, Oplopanax elatus (Nakai) Nakai, Sprague-Dawley Rat, Single oral dose toxicity
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